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endothelium-dependent vasodilator (Lembo et al, 2000; Be towski, W jcicka and Jamroz Wisniewska, 2006) It has been suggested that, in obese subjects, leptin resistance blunts this potential hypotensive action, and this would tend to raise peripheral resistance Moreover, like insulin, leptin acting centrally activates the SNS in rodents (Correia et al, 2001) and may have similar effects in humans Plasma leptin levels are commonly elevated in subjects with hypertension and are associated with increases in heart rate, plasma renin activity, and aldosterone and angiotensinogen levels (Mikhail, Golub and Tuck, 1999; Barton et al, 2003) Activation of the systemic and adipose tissue RAS has also been implicated in obesityrelated hypertension.

For example, the function in Listing 33-4 checks a software version number (as a string) to ensure that it is a valid dotted-decimal. It uses function attributes to track the number of calls and the number of successes. Listing 33-5 shows the output.

Adipose tissue expresses all the components of the RAS, and upregulation of the genes encoding angiotensinogen, renin, angiotensin-converting enzyme (ACE) and the angiotensin II type 1 (AT1) receptor has been observed in adipose tissue, in association with obesity-related hypertension (Lin et al, 2006; Iacobellis, 2005b; Sharma, 2004b) Expression of the AT1 receptor gene is twofold greater in adipocytes from obese hypertensive than in obese normotensive persons Animal studies indicate that adipocyte-derived angiotensinogen acts locally to stimulate adipocyte growth and differentiation, as well as lipid synthesis and storage in adipocytes (Kuk et al, 2006; Lin et al, 2006; Iacobellis, 2005b; Sharma, 2004b) Angiotensinogen produced in adipocytes may be released into the bloodstream, contributing to the circulating pool of angiotensinogen and angiotensin II.

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Philanthrotec, www.ptec.com. This organization provides online software, much like the other company just listed, that allows organizations to place easy-to-use calculators on their planned giving Web site allowing someone to play with the possibilities of making more esoteric, but very valuable planned gifts that includes: Charitable gift annuity Charitable remainder annuity trust Charitable remainder unitrust Pooled income fund Charitable lead annuity trust Charitable lead unitrust Life estate agreement Bequest by will or living trust But how do these calculators work Let s pretend that a Web site visitor is a 66year-old recent retiree. In the past month, the visitor s 69-year-old brother died and

As well as potentially raising blood pressure, this might be expected to enhance the ectopic storage of triglyceride in tissues such as skeletal muscle and liver, thereby decreasing insulin sensitivity Evidence from animal studies suggests that angiotensin-receptor blockers can promote redistribution of excess fat from these ectopic sites to mature adipocytes, resulting in improved insulin sensitivity (Lin et al, 2006; Iacobellis, 2005b; Sharma, 2004b) Increased adiposity is also accompanied by downregulation of adiponectin, which enhances insulin sensitivity and inhibits atherosclerosis, and reduced adiponectin is associated with increased levels of in ammatory markers such as CRP and TNF- Endothelial abnormalities such as decreased nitric oxide responsiveness are common in obesity..

* When the view is set to Fit in Window, the keystrokes move you to the next or previous page. When partial page views appear, the keystrokes scroll the page.

Most of the principles and lessons learned for designing and building data centers have accrued over the last 50 or so years. Nevertheless, a modern data center shares several aspects with ancient structures. The purpose of any building (be it a fort, cathedral, or house) is to provide a set of services. The data center s primary service is to provide care and feeding for all equipment housed within it. The practical requirements of a data center are as follows:

Action: Action Specials Action Group. Action Setup: Calling upon the Action group brings up a mini Action interface as a sort of sublevel to the main (Group) Action. You use this subinterface to add and set up each of the Actions to be grouped. To add an Action, click the Add Action button. This starts the new Action (as usual) and activates another Action pop-up menu lower down. Use the lower Action menu to choose the Action you wish to add to the group. Be careful to make your Action selection from the lower Action menu. Choosing one from the upper menu changes the Action from an Action group to the new choice. Fortunately, though, all is not necessarily lost if you do this and notice your mistake. You can use the Undo command to get back to your Action group settings.